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  1. Hatayama, M., Aruga, J. Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions. BMC Evol. Biol. [Epub ahead of print] (2010)* 解説 OpenAccess
  2. Aruga, J, Nozaki, Y., Hatayama, M., Odaka, Y.S., Yokota, N. Expression of ZIC family genes in meningiomas and other brain tumors. BMC Cancer [Epub ahead of print] (2010) * OpenAccess
  3. Katayama, K-i.,  Zine, A., Ota, M., Matsumoto, Y., Inoue, T., Fritzsch, B., Aruga, J. Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice. PLoS ONE 4, e7786 (2009)* 解説 OpenAccess
  4. Sakai-Kato, K., Umezawa, Y., Mikoshiba, K., Aruga, J., Utsunomiya-Tate, N. Stability of folding structure of Zic zinc finger proteins. Biochem Biophys Res Commun. 384:362-365 (2009)*
  5. Kinameri, E., Inoue, T., Aruga, J., Imayoshi, I., Kageyama, R., Shimogori, T., Moore, A.W.: Prdm proto-oncogene transcription factor family expression and interaction with the Hes/Notch pathway in mouse neurogenesis. PLoS ONE 3, e3859 (2008) OpenAccess
  6. Katayama, K-i, Yamada, K., Ornthanalai, V. G., Inoue, T., Ota, M., Murphy, N.P., Aruga, J.: Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Mol. Psychiatry [Epub ahead of print] (2008)* 解説
  7. Hatayama, M., Tomizawa, T., Sakai-Kato, K., Bouvagnet, P., Kose, S., Imamoto, N., Yokoyama, S., Utsunomiya-Tate, N., Mikoshiba, K., Kigawa, T., Aruga, J.: Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain, a role of conserved tryptophan residue in the zinc finger domain. Hum. Mol. Genet.17, 3459-3473 (2008) * 解説 OpenAccess
  8. Takahashi, H., Shimizu, T., Aruga, J.: Expression pattern of annelid Zic in embryonic development of the oligochaete Tubifex tubifex. Dev. Genes Evol. 218, 553-560. (2008)*
  9. Fujimi, T.J., Aruga, J.: Upstream Stimulation Factors, USF1 and USF2 are differentially expressed during Xenopus embryonic development. Gene Expr. Patterns 8, 376-381. (2008)*
  10. Inoue, T., Ogawa, M., Mikoshiba, K., Aruga J.: Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J. Neurosci. 28, 4712-4725. (2008)*解説 OpenAccess
  11. Ogawa,　M., Mizugishi, K., Ishiguro, A., Koyabu, Y., Imai, Y., Takahashi, R., Mikoshiba, K., Aruga, J.: Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Genes Cells 13, 391-409. (2008)*
  12. Ishiguro, A., Aruga, J.: Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett. 582, 154-158. (2008)*
  13. Sakai-Kato, K., Ishiguro, A., Mikoshiba, K., Aruga, J., and Utsunomiya-Tate, N.: A comprehensive study of the structural dynamics of Zic family proteins, C2H2-type zinc finger proteins, and their relationships with Gli/Glis family proteins. Biochem. Biophys. Acta 1784, 1011-1019. (2008)*
  14. Takahashi, H., Kamiya, A., Ishiguro, A., Suzuki, A.C., Saitou, N., Toyoda, A., Aruga, J.: Conservation and diversification of Msx protein in metazoan evolution. Mol. Biol. Evol. 25, 69-82. (2008)*解説 OpenAccess
  15. Aruga, J., Odaka, Y.S., Kamiya, A., Furuya, H.: Dicyema Pax6 and Zic, tool-kit genes in a highly simplified bilaterian. BMC Evol. Biol. 7, 201 (2007)*解説 OpenAccess
  16. Inoue, T., Ota, M., Ogawa, M., Mikoshiba, K., Aruga, J.: Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J. Neurosci. 27, 5461-5473. (2007)* OpenAccess
  17. Inoue, T., Ota, M., Mikoshiba, K., Aruga, J.: Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev. Biol. 306, 669-684. (2007)*
  18. Aruga, J., Yoshikawa, F., Nozaki, Y., Sakaki, Y., Toyoda, A., Furuichi, T.: An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. J. Neurochem. 102, 1533-1547. (2007)*
  19. Ishiguro, A., Ideta, M., Mikoshiba, K., Chen, D.J., Aruga, J.: Zic2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase and RNA helicase A. J. Biol. Chem. 282, 9983-9995. (2007)*
  20. Yamada, K., Gerber, D. J. Iwayama, Y., Ohnishi, T., Ohba, H., Toyota, T., Aruga, J., Minabe, Y., Tonegawa, S., Yoshikawa, T.: Genetic analysis of the calcineurin pathway identifies the EGR gene family and specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. USA 104, 2815-2820. (2007)
  21. Chhin, B., Hatayama, M., Bozon, D., Ogawa, M., Schön, P., Tohmonda, T. Sassolas, F., Aruga, J., Valard, A-G., Chen, S-C., Bouvagnet, P.: Elucidation of penetrance variability of a ZIC3 mutation in A family with complex heart defects and functional, analysis of ZIC3 mutations in the first zinc finger domain. Human Mutation 28, 563-570. (2007)
  22. Aruga, J., Kamiya, A., Takahashi, H., Fujimi, T.J., Shimizu, Y., Ohkawa, K., Yazawa, S., Umesono, Y., Noguchi, H., Shimizu, T., Saitou, N., Mikoshiba, K., Sakaki, Y., Agata, K., Toyoda, A.: A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity. Genomics 87, 783-792. (2006)*解説
  23. Fujimi, T.J., Mikoshiba, K., Aruga, J.: Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family. Dev Dyn. 235, 3379-3386. (2006)*
  24. Morimura, N., Inoue, T., Katayama, K., Aruga, J.: Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene 380, 72-83. (2006)*
  25. Futatsugi, A., Nakamura, T., Yamada, M.K., Ebisui, E., Nakamura, K., Uchida, K., Kitaguchi, T., Takahashi-Iwanaga, H., Noda, T., Aruga, J., Mikoshiba, K.: IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309, 2232-2234. (2005)
  26. Ishiguro, A., Inoue, T., Mikoshiba, K., Aruga, J.: Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem. Biophys. Res. Commun. 324, 302-307. (2004)*
  27. Aruga, J., Ogura, H., Shutoh, F., Ogawa, M., Franke, B., Nagao, S., Mikoshiba, K.: Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent-tail) mutant mice. Eur. J. Neurosci. 20, 2159-2167. (2004)*
  28. Aruga, J.: The role of Zic genes in neural development. Mol. Cell. Neurosci. 26, 205-221. (2004)*
  29. Inoue, T., Hatayama, M., Tohmonda, T., Itohara, S., Aruga, J., Mikoshiba, K.: Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.　Dev. Biol. 270, 146-162. (2004)*
  30. Mizugishi, K., Hatayama, M., Tohmonda, T., Ogawa, M., Inoue, T., Mikoshiba, K., Aruga, J.: Myogenic repressor I-mfa interferes with the function of Zic family proteins.　Biochem. Biophys. Res. Commun. 320, 233-240. (2004)*
  31. Herrera, E., Brown, L., Aruga, J., Rachel, R.A., Dolen, G., Mikoshiba, K., Brown, S. and Mason, C.A.: Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell 114, 545-557. (2003)
  32. Aruga, J., Mikoshiba, K.: Identification and characterization of Slitrk, a novel neruonal transmembrane protein family controlling neurite outgrowth. Mol. Cell. Neurosci. 24, 117-129. (2003)*
  33. Aruga, J., Yokota, N., Mikoshiba, K.: Human SLITRK family genes, genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 315, 87-94 (2003)*
  34. Aruga, J.: Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr. Patterns 3, 727-733. (2003)*
  35. Hoshino, J., Aruga, J., Ishiguro, A., Mikoshiba, K.: Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Mol. Brain Res. 120, 57-64 (2003)*
  36. Aruga, J., Tohmonda, T., H.omma S., and Mikoshiba K.: Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev. Biol. 244, 329-341. (2002)*
  37. Aruga, J., Inoue, T., Hoshino, J. and Mikoshiba, K.: Zic2 controls the cerebellar development in cooperation with Zic1. J. Neurosci. 22, 218-225. (2002)*
  38. Kitaguchi, T., Mizugishi, K., Hatayama, M., Aruga, J. and Mikoshiba, K.: Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev. Growth Diff. 44, 55-61. (2002)*
  39. Koyabu, Y., Nakata, K., Mizugishi, K., Aruga, J. and Mikoshiba, K.: Physical and functional interaction between Zic and Gli proteins. J. Biol. Chem. 276, 6889-6892. (2001)*
  40. Mizugishi, K., Aruga, J., Nakata, K., Mikoshiba, K.: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 276, 2180-2188. (2001)*
  41. Salero, E., Perez-Sen, R., Aruga, J., Gimenez and, C. and Zafra, F.: Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. J. Biol. Chem. 276, 1881-1888. (2001)*
  42. Maeda, R., Mood, K., Jones, T.L., Aruga, J., Buchberg, A.M., Daar I.O.: Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos. Oncogene 20, 1329-1342. (2001)
  43. Ogura, H., Aruga, J., Mikoshiba, K.: Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders. Behav. Genet. 31, 317-324. (2001)*
  44. Kitaguchi, T., Nakata, K., Nagai, T., Aruga, J. and Mikoshiba, K.: Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev. Genes Evol. 211, 309-314. (2001)*
  45. Tamura, T., Hashimoto, M., Aruga, J., Konish, Y., Nakagawa, M., Ohbayashi, T., Shimada, M., Mikoshiba, K.: Promoter structure and gene expression of the mouse inositol 1,4,5-trisphosphate receptor type 3 gene.　Gene　275, 169-176. (2001)
  46. Nagai, T., Aruga, J., Minowa, O., Sugimoto, T., Ohno, Y., Noda T. and Mikoshiba, K.:Zic2 regulates the kinetics of neurulation. Proc. Natl. Acad. Sci. USA 97, 1618-1623. (2000)*
  47. Kitaguchi, T., Nagai, T., Nakata, K. Aruga, J., Mikoshiba, K.: Zic3 is involved in the left-right asymmetry as a left signal mediator in Xenopus embryo. Development 127, 4787-4795. (2000)*
  48. Nakata, K., Koyabu, Y., Aruga, J., Mikoshiba, K.: A novel member of Xenopus Zic family, Zic5, specifically mediates neural crest development. Mech. Dev. 99, 83-91 (2000)*
  49. Aruga, J., Shimoda, K. and Mikoshiba, K.: A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord. Mol. Brain Res. 78, 15-25. (2000)*

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